A multiaspect study on transcytosis mechanism of sorafenib nanogranules engineered by high-gravity antisolvent precipitation.
Yin Y, Deng H, Wu K, He B, Dai W, Zhang H, Fu J, Le Y, Wang X, Zhang Q.
Yin Y, et al.
J Control Release. 2020 Jul 10;323:600-612. doi: 10.1016/j.jconrel.2020.04.008. Epub 2020 Apr 9.
J Control Release. 2020.
PMID: 32278828
Pharmacokinetics in rats demonstrated an obvious superiority of SFN-NGs in oral absorption and lymphatic transfer over SFN crude drugs. Different from free SFN, SFN-NGs could be internalized in cells in early stage by caveolin/lipid raft or clathrin induced endocytosis, an …
Pharmacokinetics in rats demonstrated an obvious superiority of SFN-NGs in oral absorption and lymphatic transfer over SFN crude drug …